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Signaling by CD40-reactive NAbs restores normal phenotypes of DCs from patients with XLA. DCs from patients with XLA were differentiated in the presence of GM-CSF, IL-4, and 10% autologous plasma for 6 days. DCs were stimulated with either CD40-reactive natural IgG (3 μM) (A Lower) or F(ab′)2 fragments of CD40-reactive NAbs (1.5 μM) (B Lower) during the last 48 h of culture. The percentage of cells that are positive for the indicated markers is shown, and MFIs are shown in parentheses.
