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. 2004 Sep 20;101(39):14270–14275. doi: 10.1073/pnas.0405709101

Fig. 6.

Fig. 6.

History-dependent BLA control of MPP–DG plasticity. (A) Plasticity displayed by BLA–DG synapses. The ordinate (Right) indicates the slopes of BLA-evoked fEPSPs in the DG. The traces (Left) represent BLA-evoked DG responses 5 min before and 5 min after application of either TBS or four-pulse LFBS to the BLA. *, P < 0.05 vs. before; paired t test. Data are means ± SE of each five to eight rats. (B) Representative time courses of MPP-evoked fEPSPs after coapplication of eight-pulse MPP LFBS and four-pulse BLA-LFBS 5 min after priming stimulation of either TBS (Upper) or LFBS (Lower) to the BLA. MPP plasticity was induced 5 min after the BLA priming. (C) Positive correlations between BLA–DG synaptic strength and the degree of the BLA modulation of MPP synaptic plasticity. The ordinate indicates fEPSP slopes from 50 to 60 min after application of MPP–BLA LFBS, which was applied 5 min after BLA priming (TBS or LFBS). The abscissa indicates BLA–DG fEPSP slopes immediately before the induction of MPP plasticity. Each symbol represents one animal. Solid lines are the best linear fit to the data (r = 0.547, df = 22; P = 0.006). (D) Lack of the effect of BLA priming on homosynaptic modifications induced by LFBS of the MPP alone. TBS was applied to the BLA 5 min before eight-pulse LFBS of the MPP. Data are the average of fEPSP slopes from 50 to 60 min after MPP LFBS (means ± SE of five rats).