Figure 2.

CHAOS-DIALIGN correctly aligns the SCL promoter and a conserved non-coding sequence in exon 1. The alignment was extracted from the CHAOS-DIALIGN global alignment of SCL sequences from human, mouse, chicken, zebrafish, and pufferfish. Consensus binding motifs are labelled. All except YY1 have been previously demonstrated to be essential for the appropriate pattern or level of SCL expression. The factors binding conserved sequence (CS) 1 and 2 are unknown. Shading of bases is at (grey) and (black) conservation.