Table 1.
Pb apiG3PAT (−) parasites show reduced sporozoite infectivity in vivo.
Strain | Route | Sporozoites | Fraction patent | Days to patencya |
---|---|---|---|---|
Pb apiG3PAT (−) | Intravenous | 10 000 | 5/6 | 8.8 |
Wild type | Intravenous | 10 000 | 6/6 | 4.2 |
Pb apiG3PAT (−) | Intravenous | 1000 | 1/6 | 10 |
Pb ANKA WT | Intravenous | 1000 | 4/6 | 5.8 |
Pb apiG3PAT (−) | Mosquito bite | 10 mosquitoes | 1/6 | 11 |
Pb ANKA WT | Mosquito bite | 10 mosquitoes | 6/6 | 4.5 |
Mean days to patency calculated from mice that developed a patent infection.