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. 2017 Jan 5;120(1):99–109. doi: 10.1161/CIRCRESAHA.116.309937

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© 2016 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Recovery of blood flow and revascularization in ischemic hindlimbs after femoral artery ligation in diabetic and AMPKα2^−/− mice. A, Reperfusion after femoral artery ligation as measured by laser Doppler analysis in wild-type (WT) and AMPKα2^−/− littermates (n=9 per group). B, Micro computed tomography angiography of ligated limbs from WT and AMPKα2^−/− mice 7 d post surgery. Arrows indicate site of ligation. Similar results were obtained in an additional 2 animals in each group. C, CD31+ capillaries in transverse sections of ischemic gastrocnemius muscles from WT and AMPKα2^−/− mice (bar=100 µm; n=4 per group). *P<0.05, **P<0.01, ***P<0.001 vs control group. AMPK indicates AMP-activated protein kinase.