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. 2017 Jan 12;2(1):e89504. doi: 10.1172/jci.insight.89504

Figure 5. Circulating levels of ATP, ADP, AMP, and adenosine after myocardial infarction.

Figure 5

Circulating extracellular (A) ATP, (B) ADP, (C) AMP, and (D) adenosine concentrations were measured 48 hours after myocardial infarction using liquid chromatography–mass spectrometry. Metabolites were normalized to the amount hemolysis initially present in the sample. ATP was found to be elevated in the plasma of cd39–/– mice compared with cd39+/+ mice. There were no differences in circulating ADP, AMP, or adenosine levels between groups. (E) CD73 expression after myocardial infarction was evaluated using flow cytometry 4 days after myocardial infarction. There was no difference in (F) total or (G) leukocyte CD73 expression between cd39+/+ and cd39–/– mice. 10,000 events were captured per sample. n = 3 per group. Student’s t test, *P < 0.05. Box and whisker plots show median (line within box), upper and lower quartiles (bounds of box), and minimum and maximum values (bars).