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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Pediatr Infect Dis J. 2017 Jan;36(1):36–43. doi: 10.1097/INF.0000000000001342

Figure 4. Multi-way sensitivity analysis of the incremental cost-effectiveness of diagnostic algorithms for pediatric TB in a high TB-Burden country referral hospital, accounting for varying Sensitivity of Current Clinical Diagnosis.

Figure 4

This figure evaluates three different scenarios of sensitivity under the current standard of care: Panel A assumes a 30% sensitivity of the current clinical algorithm, Panel B a sensitivity of 50%, and Panel C a sensitivity of 86%. Improving the Current Clinical Diagnosis makes Xpert (or MODS) more likely to be cost-effective relative to empirically “Treat All” children, because fewer children with true underlying TB are left without a diagnosis.