Table 1.
Lipid synthesis genes downregulated in 3 and 13 month transgenic PLP-FLAG-LMNB1 mice.
| Fold change relative to wild types |
||||
|---|---|---|---|---|
| Gene Symbol | Full name | 3 month | 13 month | Enriched in myelinating oligodendrocyte |
| Ldlr | Low-Density Lipoprotein (LDL) Receptor | 0.71 | 0.31 | Yes |
| Cyp51 | Lanosterol 14-demethylase (CYP51) | 0.75 | 0.37 | Yes |
| Hmgcs1 | 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 | 0.65 | 0.38 | Yes |
| Sqle | Squalene Epoxidase | 0.75 | 0.41 | No |
| Sc4mol | Methylsterol Monooxygenase | 0.71 | 0.41 | Yes |
| Hmgcr | 3-Hydroxy-3-Methylglutaryl-CoA Reductase | 0.74 | 0.55 | Yes |
| Scd1 | Stearoyl-CoA desaturase-1 | 0.62 | 0.55 | Yes |
| Dhcr7 | DHCR7 7-dehydrocholesterol reductase | 0.73 | 0.58 | Yes |
| Elovl7 | ELOVL Fatty Acid Elongase | 0.74 | 0.69 | Yes |