TABLE 3.

Renal biochemistry (24-h urine)

	SHRSP (n = 17)	WKY (n = 18)	3a (n = 9)	3d (n = 7)	3f (n = 6)	P value
Volume drank (ml)	78.62 ± 21.79	53.12 ± 30.74a	58.47 ± 9.43	57.55 ± 15.23	79.16 ± 16.78	0.010
Urine volume (ml)	55.29 ± 15.78	31.80 ± 14.34a	34.03 ± 7.02a	30.68 ± 11.32a	55.86 ± 8.67	<0.001
Na (mmol/l)	211.14 ± 46.41	220.23 ± 71.19	268.97 ± 32.70a	260.49 ± 36.69	169.89 ± 27.46	0.004
K (mmol/l)	44.48 ± 17.37	71.25 ± 33.04a	72.41 ± 20.37a	80.72 ± 27.00a	28.25 ± 8.59	<0.001
Urea (mmol/l)	131.16 ± 57.62	235.52 ± 90.62a	228.93 ± 62.26a	316.61 ± 113.57a	103.00 ± 34.23	<0.001
Creatinine (mmol/l)	1.71 ± 0.69	3.47 ± 1.32a	2.60 ± 0.45	3.09 ± 0.90a	1.34 ± 0.38	<0.001
Na/creatinine	180.51 ± 87.06	70.05 ± 30.37a	105.18 ± 15.73a	89.76 ± 24.74a	131.49 ± 24.69	<0.001
K/creatinine	37.57 ± 9.75	20.85 ± 6.48a	27.62 ± 4.32a	26.15 ± 4.13a	21.10 ± 2.41a	<0.001
Urea/creatinine	112.69 ± 29.95	68.85 ± 9.11a	87.33 ± 12.81a	101.15 ± 8.47	76.34 ± 4.14a	<0.001

SHRSP, stroke-prone spontaneously hypertensive; WKY, Wistar–Kyoto.

^aStrain is significantly different from SHRSP.