Table III.
A list of different types of GAMs investigated for induction of bone formation
| Scaffold material | Vector | Transgene | Model |
|---|---|---|---|
| Collagen(89) | pDNA | PTH 1–34 or/and BMP-4 | Rat femoral defect |
| Collagen(29) | pDNA | PTH 1–34 | Dog tibial defect |
| PLGA(90) | PEI-pDNA complexes | BMP-4 | Rat cranial defect |
| Poly(propylene fumarate)(91) | Triacrylate/amine polycationic polymer-pDNA polyplexes complexed with gelatin microparticles | BMP-2 | Rat cranial defect |
| Collagen(34) | PEI-pDNA complexes | PDGF-B | Rat cranial defect |
| Collagen or autologous bone graft(92) | BMP-2 condensed with liposomal vector | BMP-2 | Pig cranial defect |
| Collagen(93) | CaP-pDNA precipitates | BMP-2 | Rat tibial defect |
| Collagen(94) | pDNA | PTH 1–34 | Lumbar interbody fusions in sheep |
| Collagen(95) | pDNA | VEGF165 | Rabbit radial defect |
| Calcium phosphate cement(96) | pDNA complexed with poly(ethyleneglycol) (PEG)-block-polycation | caALK6 and Runx2 | Mouse cranial defect |
| Collagen(97) | pDNA | Osteogenic protein-1 (OP-1 or BMP-7) | Rat lumbar interbody arthrodesis |
| Collagen/calciumphosphate(98) | pDNA complexed with PAMAM dendrimer | VEGF165 | Mouse intra-femoral defect |
| Hydroxyapatite(99) | pDNA condensed with cationic liposomes | BMP-2 | Rabbit cranial defect |
(PEG-b-P[Asp-(DET)]): PEG-b-polyasparagine carrying the N-(2-aminoethyl) aminoethyl group (CH2)2NH(CH2)2NH2 as the side chain)
caALK6: constitutively active form of activin receptor-like kinase 6
Runx2: runt-related transcription factor 2