Skip to main content
. Author manuscript; available in PMC: 2017 May 21.
Published in final edited form as: Lab Invest. 2016 Nov 21;97(1):34–42. doi: 10.1038/labinvest.2016.113

Figure 3. Diabetes impairs perfusion in WT mice but not RAGE KO mice.

Figure 3

Ischemia was induced in mice using the HLI procedure in either healthy or STZ treated diabetic mice (DM). LPDI was used to noninvasively measure the reperfusion of the limb. A) The perfusion ratio between the ischemic and non-ischemic leg on post-op day 21 shows in impaired perfusion in WT+DM but not in RAGE KO mice. Mean and SEM are plotted, * indicates p<0.05 vs WT, ** indicates p<0.001 vs WT, and # indications p<0.001 vs WT+DM (n=4–12). B) Representative LDPI images of (a) WT (b) RAGE KO (c) WT + DM (d) RAGE KO + DM. (IL=Ischemic Leg; NIL=Non-ischemic Leg).