Figure 3. Illustration of the BRCA1 and BRCA2 genes, including exons, introns, and functional domains noting location of BRCA mutations in the patient-derived-xenograft (PDX) models.

RING, really interesting new gene; PALB2, partner and localizer of BRCA2; BRCT, BRCA1 C-terminal; OB, oligonucleotide/oligosaccharide-binding domain.