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. 2016 Dec 8;7(6):585–596. doi: 10.1080/19491034.2016.1260803

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© 2016 The Author(s). Published with license by Taylor & Francis.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Effects of FTI on lamins relative stabilities in human fibroblasts. (A) Western blotting analysis of viral infected fibroblasts upon the treatment of FTI. DMSO treated cells were mock control. (B) Quantification of the relative stability in (A) is presented as EGFP/luciferase ratios. Bar graph shows the average of day 4 to day 6 data. Results were generated from 3 biological replicates. *P < 0.05, **P < 0.01. P2A-LA, P2A-PG and P2A-LB1 refer to the constructs of luciferase-P2A-lamin A, luciferase-P2A-progerin and luciferase-P2A-lamin B1.