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. Author manuscript; available in PMC: 2017 Jan 5.
Published in final edited form as: ACS Sens. 2016 Aug 10;1(8):975–978. doi: 10.1021/acssensors.6b00396

Figure 4.

Figure 4

Flow cytometry of the cell entry dynamics of Rho-Gd44-G5-ss-Bt-pHLIP3 conjugate (particle is attached to C-terminus of the peptide) in MSC (a) (mesenchymal stem cell), U251 (b), MDA-MB-231 (c) and U87 (d) cell lines. The log of rhodamine adsorption intensity (FL1-H on X axis is plotted against the number of cells (counts on y axis). No cellular uptake of the nanoparticle in normal MSC (a) was observed for both pH (6.5 and 7.4). In contrast, the cellular uptake of the nanaoparticle in all three cancer cell lines (b, c & d) is evident at lower pH 6.5. (black line) Control (no probe at pH 7.4); (red line) nanoparticle at pH 7.4; (blue line) nanoparticle at pH 6.5.