Table 1.

EOG responses to heptaldehyde in X4^−/−; B1^ΔCaM mice^a

	[Heptaldehyde]	Wild-type		Nckx4−/−		CNGB1ΔCaM		Nckx4c−/−; CNGB1ΔCaM		Significanceb
		Mean ± SEM	N	Mean ± SEM	N	Mean ± SEM	N	Mean ± SEM	N
Single brief pulse
EOG amplitude (mV)	10−4 m	5.54 ± 0.69	6	5.82 ± 0.69	5	4.72 ± 0.51	7	1.85 ± 0.25	7	***, ††, †††
	10−3 m	9.07 ± 0.85	6	9.62 ± 0.79	5	7.99 ± 0.71	7	3.90 ± 0.41	7	***, ††, †††
Time to peak (ms)	10−4 m	419.00 ± 10.15	6	409.20 ± 15.59	5	433.07 ± 7.56	7	445.86 ± 8.48	7	NS
	10−3 m	459.75 ± 14.93	6	455.20 ± 15.86	5	465.29 ± 12.66	7	492.93 ± 11.33	7	NS
Rise rate (mV/s)	10−4 m	20.31 ± 2.92	6	24.33 ± 4.50	5	16.33 ± 2.08	7	6.21 ± 0.94	7	***, ††, †††
	10−3 m	29.38 ± 3.25	6	34.14 ± 4.95	5	25.42 ± 2.91	7	11.47 ± 1.44	7	***, ††, †††
Termination (mV ∗ s)	10−4 m	0.78 ± 0.09	6	3.05 ± 0.22	5	1.17 ± 0.07	7	2.62 ± 0.25	7	*, ***, †, †††
	10−3 m	1.60 ± 0.10	6	3.99 ± 0.16	5	2.28 ± 0.08	7	3.50 ± 0.23	7	*, **, ***, †, †††
Second response
Second response latency (ms)	10−4 m	123.00 ± 2.30	5	174.00 ± 7.46	4	119.83 ± 3.02	6	147.08 ± 2.76	6	*, **, †, ††, †††
	10−3 m	132.40 ± 2.95	5	183.75 ± 8.30	4	123.58 ± 3.58	6	144.50 ± 2.07	6	*, †, ††, †††
Time to second peak (ms)	10−4 m	276.50 ± 7.08	5	311.13 ± 8.32	4	295.17 ± 4.44	6	300.00 ± 7.34	6	*
	10−3 m	300.80 ± 5.82	5	326.63 ± 6.60	4	314.42 ± 6.80	6	307.67 ± 6.96	6	NS
Response ratio (ratio of second pulse to first pulse)	10−4 m	57.00 ± 1.83	5	18.20 ± 1.47	4	62.85 ± 2.40	6	25.84 ± 2.75	6	*, ***, †, †††
	10−3 m	37.66 ± 2.65	5	13.03 ± 0.81	4	43.59 ± 1.54	6	20.74 ± 2.44	6	*, ***, †, †††
Sustained pulse
EOG amplitude (mV)	10−4 m	8.59 ± 1.03	5	8.83 ± 1.33	4	7.34 ± 0.39	6	3.73 ± 0.79	6	***, ††, †††
	10−3 m	13.24 ± 1.32	5	13.03 ± 1.69	4	11.14 ± 0.38	6	6.61 ± 1.17	6	***, ††, †††
Time to peak (ms)	10−4 m	469.50 ± 27.48	5	593.00 ± 54.67	4	708.17 ± 40.28	6	663.00 ± 24.29	6	**, ***
	10−3 m	520.00 ± 24.78	5	616.50 ± 57.36	4	700.00 ± 24.15	6	777.08 ± 66.10	6	***
Area under decay (mV ∗ s)	10−4 m	4.40 ± 0.17	5	5.47 ± 0.22	4	5.92 ± 0.16	6	5.20 ± 0.12	6	*, **, ***, †††
	10−3 m	5.46 ± 0.22	5	6.33 ± 0.26	4	6.34 ± 0.15	6	5.94 ± 0.07	6	*, **

^aError is represented as SEM. The number of mice is indicated, with one recording per mouse per concentration.

^bOne-way ANOVA followed by Tukey's multiple comparison test. Comparisons are as follows:

*WT versus X4^−/−.

**WT versus B1^ΔCaM.

***WT versus X4^−/−; B1^ΔCaM.

†X4^−/− versus B1^ΔCaM.

††X4^−/− versus X4^−/−; B1^ΔCaM.

†††B1^ΔCaM versus X4^−/−; B1^ΔCaM.