Figure 4.

Sim1-Cre Glp1r KD attenuates cardiovascular responses to acute restraint. A–C, Baseline recordings of blood pressure (A), HR (B), and total activity (C) revealed no significant differences between the genotypes. There were main effects of time on blood pressure and activity, consistent with known circadian patterns. D–G, Exposure to acute restraint induced significant increases in blood pressure (MAP) and HR (BPM) that were attenuated in Sim1-Cre; Glp1r^f/f mice. *Significant difference from Glp1r^f/f (n = 7 or 8 per group). H, Sim1-Cre; Glp1r^f/f mice showed less sympathetic cardiac tone following restraint, but there was no difference in the parasympathetic drive to the heart. I, HR response following total ganglionic blockade with hexamethonium did not differ between the genotypes. Data are mean ± SEM.