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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Brain Behav Immun. 2016 Nov 7;60:282–292. doi: 10.1016/j.bbi.2016.11.003

Figure 3. Function-blocking MT1-MMP antibody (hAb-DX2400) attenuates CCI-induced allodynia.

Figure 3

von Frey testing after i.n. injection of the hAb- DX2400 (n=11), mAb-9E8 (n=4), or IgG1 (n=9), 1.0 mg/ml, each, at day 3 after CCI. von Frey testing was done in the hind paws ipsilateral and contralateral to injection. The mean withdrawal threshold (gram-force; g) ± SEM. Thresholds corresponding to naïve and allodynic animals are shown for reference. *, p≤0.01, hAb-DX2400 vs. IgG1 by repeated measures ANOVA with Bonferroni’s corrections.