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. 2017 Jan 5;7:40159. doi: 10.1038/srep40159

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Copyright © 2017, The Author(s)

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(a) Insulin sensitivity test, fasted mice (8 am–2 pm) were injected with insulin i.p. and blood glucose measured at time 0 and 30 minutes post insulin exposure. (b) Glucagon sensitivity test, fasted mice (8 am–2 pm) were injected with glucagon i.p. and blood glucose measured at time 0 and 10 minutes post glucagon exposure. n = 12 per group. Statistical significance (P) was determined by multiple comparisons Two-way ANOVA test. The data is showed as the mean ± S.E.M. **p < 0.01 or ***p < 0.001 compared to the control (Ctr) chow or control (Ctr) high fat mice.