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Blockade of KCa3.1 attenuated β-amyloid burden in the brains of TgAPP/PS1 mice. Mouse anti-6E10 monoclonal antibody was used to detect senile plaques in (A) brain cortex and (C) hippocampus of WT, TgAPP/PS1, and TgAPP/PS1 + TRAM-34 (120 mg/kg) groups (n = 10 per group). Quantification of senile plaque numbers in (B) cortex and (D) hippocampus. Data represent mean ± SEM. ##p < 0.01, versus WT mice. ∗∗p < 0.01, versus vehicle-treated TgAPP/PS1 mice. Scale bar: 50 μm.
