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. 2017 Jan 5;7:39899. doi: 10.1038/srep39899

Figure 3. Hepatic overexpression of miR-291b-3p results in hyperglycemia and insulin resistance in C57BL/6 J mice.

Figure 3

(A) GTT in C57BL/6 J mice on 7 days after injection of adenovirus- miR-291b-3p-mimic (Ad-miR-291m) or adenovirus-GFP (Ad-NC). (B) ITT in C57BL/6 J mice on 7 days after injection of Ad-miR-291m or Ad-NC. (C) PTT in C57BL/6 J mice on 7 days after injection of Ad-miR-291m or Ad-NC. (D) Euglycemic-hyperinsulinemic clamp assay in C57 mice on 7 days after injection of Ad-miR-291m or Ad-NC. (E) The glycogen content in the liver of C57BL/6 J mice on 7 days after injection of Ad-miR-291m or Ad-NC. (F) The glucose production in the liver of C57BL/6 J mice on 7 days after injection of Ad-miR-291m or Ad-NC. (G) The glycogen content in the NCTC1469 cells transfected with miR-291b-3p mimic (miR-291m). (H) The glucose level in the medium of NCTC1469 cells transfected with miR-291m. Data are expressed as mean ± SEM (n = 5). *P < 0.05; **P < 0.01; ***P < 0.001 vs. control group.