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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Brain Struct Funct. 2016 Jul 4;222(2):1007–1026. doi: 10.1007/s00429-016-1261-6

Figure 8.

Figure 8

The DOPR agonist, SNC80, attenuated the anxiogenic effects of yohimbine. Rats were pretreated with the selective DOPR agonist, SNC80 10 mg/kg, or vehicle 30 minutes prior to yohimbine administration. Anxiety-like behaviors were measured using the elevated zero maze. Time spent on the open quadrants of the zero maze was lower after yohimbine administration as compared with vehicle controls, indicating an anxiogenic response. The anxiogenic effects of yohimbine were significantly blocked by treatment with SNC80. Data are expressed as means + SEM. ** P<0.01 veh/yohimbine vs veh/veh; ### P<0.001 SNC80/yohimbine vs veh/yohimbine. N=8/group.