Table 1.

Effects of TLR receptor knockout on ischemic injury outcome.

GM mouse	Outcome in stroke	Reference
TLR2	Reduced lesion size at 1–3 days after stroke	(Lehnardt et al., 2007; Tang et al., 2007; Ziegler et al., 2007)
	Reduced lesion size at day 3 post-stroke, but increased sizes on days 7 and 14, this was associated with increased apoptosis	(Bohacek et al., 2012)
TLR3	No effect on lesion size	(Hyakkoku et al., 2010)
TLR4	Reduced lesion size at 1–3 days after stroke	(Cao et al., 2007; Caso et al., 2007; Hyakkoku et al., 2010; Kilic et al., 2008; Tang et al., 2007)
	Reduced lesion size associated with better neurological score when measured at post-stroke day 7	(Caso et al., 2007)
	TLR4 KO mice have bigger lesion size than wild-type controls in ischemic preconditiong-induced neuroprotection	(Pradillo et al., 2009)
TLR9	No effect on lesion size	(Hyakkoku et al., 2010)