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. Author manuscript; available in PMC: 2018 Jan 3.
Published in final edited form as: Structure. 2016 Dec 1;25(1):180–187. doi: 10.1016/j.str.2016.11.007

Figure 1. Inhibition of ELIC by n-alcohols.

Figure 1

(a) Representative current traces of Xenopus laevis oocytes expressing ELIC, showing ethanol inhibition of the current elicited by the agonist propylamine (PPA). The horizontal and vertical scale bars represent 1 μA and 30 sec, respectively. (b) Concentration-dependent inhibition of ELIC by n-alcohols. All data were normalized to the current at EC20 in the absence of alcohols and fit to the Hill equation (solid lines, n ≥ 6). The best-fit IC50 values for ethanol (•), 2-bromoethanol (×), n-propanol (○), n-butanol (▲), n-hexanol (□), and n-nonanol (◆) are reported in the main text as the mean ± SEM. Error bars less than the symbols sizes are not visible.