Table 1. Animal characteristics and metadata.

	Control diet		Western diet		Diet	Birth weight	Interaction
	NBWa (n = 9)	LBWb (n = 10)	NBW (n = 6)	LBW (n = 8)
Distribution of Sex	F:4/M:5	F:5/M:5	F:2/M:4	F:5/M:3
Body weight (g)	752.13 ± 36.00	648.46 ± 42.15	704.45 ± 27.9	585.99 ± 46.59	NSc	P < 0.05	NS
Daily energy intake (kcal)	149.94 ± 5.48	192.98 ± 22.16	213.92 ± 9.40	210.81 ± 19.17	P < 0.05	NS	NS
Liver Triglycerides	3.92 ± 0.74	5.51 ± 1.08	68.40 ± 11.39	75.74 ± 14.20	P < 0.0001	NS	NS
Blood analysis
ALBd	4.04 ± 0.10	3.50 ± 0.41	4.20 ± 0.17	4.33 ± 0.17	P < 0.05	NS	NS
ALPe	62.40 ± 11.30	43.00 ± 8.50	65.14 ± 7.67	76.67 ± 7.56	NS	NS	NS
ALTf	49.20 ± 3.11	49.00 ± 5.58	94.57 ± 16.40	125.50 ± 32.57	P < 0.05	NS	NS
BAg	58.80 ± 21.26	46.00 ± 19.09	59.43 ± 10.19	63.33 ± 16.67	NS	NS	NS
BUNh	27.80 ± 35.60	26.75 ± 4.77	33.57 ± 4.35	28.83 ± 2.01	NS	NS	NS
TBILi	0.05 ± 0.05	0.20 ± 0.00	0.23 ± 0.04	0.10 ± 0.06	NS	NS	P < 0.05
Cholesterol	77.00 ± 14.08	72.50 ± 15.18	418.00 ± 41.07	449.67 ± 30.41	P < 0.0001	NS	NS

Notes.

^aNBW, Normal birth weight, or >90 g.

^bLBW, Low birth weight, or <85 g.

^cNS, Not significant.

^dALB, Albumin.

^eALP, Alkaline Phosphatase.

^fALT, Alanine Aminotransferase.

^gBA, Bile Acids.

^hBUN, Blood Urea Nitrogen.

ⁱTBIL, Total Bilirubin.

Values are represented as mean ± the standard error of the mean. Significance tests were performed using 2-way ANOVA.