Table 1.
Characteristics and Outcomes of Patients Stratified by Presence of Computed Tomography Imaging and Interstitial Lung Abnormality Status
| No Chest CT for Review (n = 233; 51%) | Chest CT Available for Review (n = 227; 49%) |
P Value |
|||||
|---|---|---|---|---|---|---|---|
| No ILA (n = 113; 50%) | Indeterminate (n = 95; 42%) | ILA (n = 19; 8%) | |||||
| Comparison of No CT vs. CT | Comparison of No ILA vs. ILA | ||||||
| Baseline characteristics |
|||||||
| Age, yr, mean ± SD |
58 ± 17 | 58 ± 15 | 57 ± 15 | 58 ± 13 | 0.9 | 0.96 | |
| Sex, female, n (%) |
107 (46) | 59 (52) | 40 (42) | 8 (42) | 0.9 | 0.5 | |
| Race, white, n (%) |
182 (78) | 93 (82) | 73 (77) | 15 (79) | 0.7 | 0.8 | |
| APACHE II score, mean ± SD |
25 ± 9 | 26 ± 9 | 26 ± 8 | 25 ± 7 | 0.08 | 0.6 | |
| History of smoking, yes, n (%) |
106 (56) | 43 (46) | 49 (62) | 8 (47) | 0.6 | 1.0 | |
| History of respiratory disease, yes, n (%) |
74 (32) | 35 (31) | 45 (47) | 8 (42) | 0.02 | 0.4 | |
| History of malignancy, yes, n (%) |
74 (32) | 74 (65) | 56 (59) | 14 (74) | <0.0001 | 0.6 | |
| Time from CT scan to ICU admission, d, median (IQR) |
— | 82 (156) | 50 (110) | 22 (120) | — | 0.4 | |
| ICU characteristics and outcomes |
|||||||
| Among patients with sepsis/SIRS, reason for ICU admission, n (%) |
|||||||
| Sepsis/SIRS alone |
95 (41) | 64 (57) | 37 (39) | 6 (32) | 0.001 | 0.0005 | |
| Plus respiratory failure |
68 (29) | 28 (25) | 43 (45) | 13 (68) | |||
| Plus encephalopathy |
13 (6) | 7 (6) | 2 (2) | — | |||
| Plus cardiac arrest |
8 (3) | 1 (1) | 1 (1) | — | |||
| Plus other* |
49 (21) | 13 (11) | 12 (13) | — | |||
| ARDS diagnosis, n (%) |
33 (14) | 17 (15) | 26 (27) | 14 (74) | 0.002 | <0.0001 | |
| 28-day mortality, yes, n (%) | 31 (13) | 24 (21) | 23 (24) | 7 (37) | 0.004 | 0.05 | |
Definition of abbreviations: APACHE = Acute Physiology and Chronic Health Evaluation; ARDS = acute respiratory distress syndrome; CT = computed tomography; ICU = intensive care unit; ILA = interstitial lung abnormalities; IQR = interquartile range; SIRS = systemic inflammatory response syndrome.
*
Other includes: pulmonary emboli, thrombotic thrombocytopenic purpura, hyponatremia, diabetic ketoacidosis, hyperkalemia, transfusion reaction, hemorrhagic shock, hyperosmolar hyperglycemic state, anaphylaxis, lung transplant, incarcerated hernia, and pancreatitis.