Fig. 1.

Effects of MEM (20 mg) on PPI (a) and MMN (b) in the present cohort of HS and CPD subjects, as reported recently (Swerdlow et al. 2016). (Number sign) significant main effect of drug; (asterisk) significant effect of diagnosis; oddball type: (P)—pitch, (D)—duration, and (C)—combined P and D. Importantly, these effects provide evidence that MEM engaged neural “targets” in the present cohort, i.e., forebrain circuitry regulating PPI and MMN, immediately prior to the MCCB testing reported in this paper