Fig. 2.

Effects of acute administration of MEM (PBO vs. 10 mg po (a) and PBO vs. 20 mg po (b)) on MCCB performance (cognitive domain T-score and composite score) in HS (n = 41) and CPD subjects (n = 41). MCCB domains: SP—speed of processing; AV—attention/vigilance; WM—working memory; VL—verbal learning; VsL—visual learning; RP—reasoning and problem solving; SC—social cognition. (Number sign) significant main effect of drug; (asterisk) significant effect of diagnosis. Alternative strategies were explored for understanding differential MEM effects across domains, including parsing MCCB domains into those incorporating a timing/speed demand (SP, AV, RP) vs. those without such a demand (WM, VL, VisL, SC) (Fig. S2)