Table 1.

PBO MCCB performance (post-placebo)

PBO MCCB domain T-score	All subjects
Main analysis with diagnosis as between-subject factor
Diagnosis (Dx)	F = 38.71, df (1,78), p < 0.0001
Domain	F = 10.72, df (6, 468), p < 0.0001
Domain × Dx	F = 4.13, df (6, 468), p = 0.0005
Additional analyses with either sex/age/test order/dose as between-subject factor
1. Gender	F < 1
2. Age (median split)	F = 6.35, df (1,78), p = 0.01
Age × domain	F = 2.83, df (6, 468), p = 0.01
Age × Dx	F < 1
Age × domain × Dx	F < 1
3. Test order	F = 4.94, df (1,78), p < 0.03
Test order × domain	F = 2.46, df (6, 468), p < 0.025
Test order × Dx	F < 1
4. Dose	F < 1
Dose × Dx	F = 5.23, df (1,78), p < 0.025
Dose × domain	NS
Dose × domain × Dx	NS
In CPD subjects only
5. Smoking status (SS)	F < 1
Domain × SS	F = 3.82, df (6, 234), p < 0.002
PBO composite T-score	CPD subjects
Anticholinergic activity (low vs. high, split >15/≤ 15)	F = 8.71, df (1,35), p = 0.005
Correlation(s) vs. PBO composite T-score
Global assessment of function score	R = 0.5, p = 0.001
Duration of illness (years)	R = 0.04, NS