Table 3.

MEM effect on MCCB performance in subjects with low vs. high MEM sensitivity on measures of PPI and MMN

MCCB cognitive domain T-score	All subjects
Main analysis with diagnosis and MEM effect on PPI as between-subject factor
	10 mg	20 mg
Diagnosis (Dx)	F = 20.41, p < 0.0001	F = 14.97, p = 0.0005
Drug	F < 1	F = 17.22, p < 0.0005
Domain	F = 9.36, p < 0.0001	F = 5.22, p < 0.0001
Lo/hi MEM effect PPI (PPI)	F < 1	F < 1
Drug × PPI × Dx	NS	F = 4.81, p < 0.04
Domain × diagnosis	NS	F = 2.82, p < 0.025
Drug × Dx	NS	F = 2.16, p < 0.05
Drug × domain × PPI × Dx	F = 2.26, p < 0.05	NS
Main analysis with diagnosis and MEM effect on MMN as between-subject factor
	10 mg	20 mg
Diagnosis	F = 25.26, p < 0.0001	F = 30.56, p < 0.0001
Lo/hi MEM effect MMN (MMN)	F < 1	F < 1
Drug	F < 1	F = 7.85, p < 0.01
Domain	F = 8.11, p < 0.0001	F = 4.13, p < 0.001
Domain × Dx	F < 1	F = 3.12, p < 0.01
Domain × Dx × MMN	F = 2.17, p < 0.05	F < 1