Figure 1.

Discordance in human and murine equivalent myeloid subsets producing IL-12 in response to T. gondii. Peripheral blood murine monocytes are defined phenotypically as CD115⁺ CD11b⁺ and further subdivided into inflammatory (Ly6C^hi) or patrolling (Ly6C^low) subsets. Similarly, human monocytes are defined as HLA-DR⁺ and subdivided into classical (CD16^neg CD14⁺), intermediate (CD16⁺ CD14⁺) and non-classical (CD16⁺ CD14^dim) subsets. In the mouse, lymphoid resident conventional DCs are CD11c⁺ MHC II⁺ and are subdivided into CD8α⁺ CD11b^neg or CD8α⁺CD11b⁺ subsets. Human peripheral blood myeloid DCs are CD11c⁺ HLA-DR⁺ and defined as either mDC1 (CD141^neg CD1c⁺) or mDC2 (CD141⁺ CD1c^neg). In this figure, the murine subsets and their human counterparts are indicated by similar coloring. The myeloid subsets that produce IL-12 in response to T. gondii tachyzoites are highlighted with a gray shadow.