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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Bioessays. 2016 Sep 26;38(12):1255–1265. doi: 10.1002/bies.201600138

Figure 1.

Figure 1

Biosynthesis of the lipid-linked oligosaccharide precursor for N-linked glycosylation and known defects in this pathway. Scheme depicting the enzymes and proteins involved in the biosynthesis of the 14-sugar lipid-linked oligosaccharide (LLO) precursor for N-glycosylation. This precursor is then transferred to nascent polypeptides by the oligosaccharyltransferase (OST) enzyme complex in a co- and post-translational manner. Red lines under the gene names denote those genes associated with known CDG defects. Mutations in the OST genes STT3A, STT3B, DDOST, TUSC3 and MAGT1 have been identified in human patients.