Fig. 4.

Mitonuclear cancer associations and eQTL data reveal directional impact of risk alleles on intrinsic apoptosis and intracellular signaling. a The cancer mitonuclear GWAS network includes three overlapping sub-networks: intrinsic apoptosis, cytoskeleton/signaling, and metabolic. Among the intrinsic apoptosis factors, tumor promoters and tumor suppressors are indicated in red and blue, respectively. b, c eQTL data for tumor suppressors and oncogenes, respectively. Direction of eQTL effect is overlaid on a using arrows. d eQTL data for cytoskeletal/signaling genes in the cancer network (direction and significance overlaid in a). e A putative model for the relationship between the cytoskeletal/signaling network and cancer risk. *p < 0.05, **p < 0.005 by one-sample t test (see Supplemental Data)