Table 3.

Area Under the Curve from the Receiver Operating Characteristic Curve Analysis Based on the (Sensitivity and the 1 − Specificity of the) 6MWD for Assessing Outcomes in Patients with a 6-, 12-, or Longer than 12-Month Follow-up

	6-Month Dataset*			12-Month Dataset†			>12-Month Dataset‡
	Total	Male	Female	Total	Male	Female	Total	Male	Female
Mortality	0.725	0.731	0.733	0.684	0.687	0.694	0.676	0.678	0.686
Hospitalization	0.610	0.610	0.595	0.598	0.599	0.598	0.594	0.581	0.681
Exacerbations	0.555	0.546	0.554	0.558	0.550	0.554	0.530	0.527	0.515

Definition of abbreviations: 6MWD = 6-minute-walk distance; 6MWT = 6-minute-walk distance test; NETT = National Emphysema Therapy Trial.

All values were statistically significant.

^*Pooled 6-month dataset includes all 11 6MWT studies (five clinical trials, five observational studies, and NETT medical treatment arm) combined.

^†The 12-month dataset includes eight 6MWT studies (two clinical trials, five observational studies, and NETT medical treatment arm) combined.

^‡The >12-month dataset includes six 6MWT studies (five observational studies and NETT medical treatment arm) combined.