Table 2.

Association of ILA Progression with Change in Spirometry Relative to Participants without ILA^*

	ILA with Progression Compared with No ILA				ILA with Progression Compared with ILA without Progression
	Unadjusted Analysis	P Value	Adjusted Analysis†	P Value	Unadjusted Analysis	P Value	Adjusted Analysis†	P Value
FEV1 decline, ml/yr	13 ± 4	0.005	14 ± 5	0.005	9 ± 9	0.3	14 ± 10	0.2
FVC decline, ml/yr	29 ± 5	<0.0001	20 ± 6	0.0005	22 ± 11	0.04	25 ± 11	0.03
FEV1/FVC, change, %	−0.2 ± 0.07	0.004	−0.06 ± 0.07	0.4	−0.1 ± 0.1	0.3	−0.08 ± 0.16	0.6

Definition of abbreviation: FHS = Framingham Heart Study; ILA = interstitial lung abnormalities.

^*P values for all analyses, both adjusted and unadjusted, are calculated using general linear models to account for familial relationships in the FHS. No ILA, n = 579; ILA without progression, n = 28; and ILA with progression, n = 72. Values are linear regression coefficients ± SE, representing the additional decline in spirometry in participants with ILA with progression versus the comparison group.

^†Adjusted analyses include additional adjustments for age, sex, body mass index, pack-years smoking, and current smoking status.