. Author manuscript; available in PMC: 2017 Jul 22.

Published in final edited form as: J Nat Prod. 2016 Jul 5;79(7):1867–1871. doi: 10.1021/acs.jnatprod.6b00203

Table 2.

Comparison of Cytotoxicity Profiles of the Three Co-produced Metabolites Against Isogenic HCT116 Cells

Compound	IC₅₀			Efficacy Relative to Parental HCT116, %
Compound	Parental	HIF-1α−/−2α −/−	Oncogenic KRAS ko (HCT116^{WT KRAS})	Parental	HIF-1α−/−2α −/−	Oncogenic KRAS ko (HCT116^{WT KRAS})
Caldoramide (5)	3.9 μM	5.2 μM	8.6 μM	100	67	100
Dolastatin 10 (1)^a	0.48 nM	65 nM	24 nM	100	74	83
Largazole (3)^a	6.41 nM	18 nM	3.7 nM	100	70	67

Values taken from reference 17.