Table 1.
Association between breast cancer subtypes, total level of TILs, lymphocytes subpopulations, and macrophages
| Frequencies per tumor subtype, N (%)* |
||||||
|---|---|---|---|---|---|---|
| Immune cell subpopulation | HER2 | Lum A | Lum B | TNBC | Total | |
| TILs low | 2 (29) | 28 (72) | 7 (37) | 1 (8) | 38 (49) | |
| TILs high | 5 (71) | 11 (28) | 12 (63) | 12 (92) | 40 (51) | |
| CD3 low | 4 (80) | 36 (92) | 12 (66) | 7 (58) | 59 (80) | |
| CD3 high | 1 (20) | 3 (8) | 6 (34) | 5 (42) | 15 (20) | |
| CD4 low | 3 (50) | 33 (84) | 13 (72) | 5 (39) | 54 (71) | |
| CD4 high | 3 (50) | 6 (16) | 5 (28) | 8 (61) | 22 (29) | |
| CD8 low | 5 (83) | 35 (90) | 14 (77) | 9 (75) | 63 (84) | |
| CD8 high | 1 (17) | 4 (10) | 4 (23) | 3 (25) | 12 (16) | |
| CD68 low | 5 (83) | 31 (80) | 11 (61) | 5 (42) | 52 (69) | |
| CD68 high |
1 (17) |
8 (20) |
7 (39) |
7 (58) |
23 (31) |
|
|
p values** |
||||||
| Subtypes | TILs | CD3 | CD4 | CD8 | CD68 | |
| Lum A−LumB | 0.01 | 0.021 | ns | ns | ns | |
| Lum A−HER2 | 0.027 | ns | ns | ns | ns | |
| Lum A−TNBC | <0.001 | 0.012 | 0.002 | ns | 0.025 | |
| Lum B−HER2 | ns | ns | ns | ns | ns | |
| Lum B−TNBC | ns | ns | ns | ns | ns | |
| TNBC−HER2 | ns | ns | ns | ns | ns | |
*
Number of samples and percentage for each subtype are presented.
**
Fisher's exact test; ns = not significant.