Table 5. Odds ratios for prostate cancer diagnosis with dietary intake by cancer detection method.
Food or nutrient intake (1 s.d.)a | All studies N=1717/3258b | Clinically-detected(4 studies) N=663/2267b | PSA-detected (ProtecT study) N=1054/1261b | P value for heterogeneityc |
---|---|---|---|---|
Red meat (31.3 g/d) | 1.00 (0.94–1.07) | 0.96 (0.87–1.06) | 1.04 (0.95–1.13) | 0.25 |
Processed meat (21.8 g/d) | 1.00 (0.94–1.07) | 0.98 (0.89–1.08) | 1.02 (0.94–1.11) | 0.55 |
Red and processed meat (39.8 g/d) | 1.00 (0.94–1.07) | 0.96 (0.86–1.06) | 1.04 (0.96–1.14) | 0.20 |
Poultry (25.1 g/d) | 1.01 (0.95–1.07) | 1.05 (0.96–1.15) | 0.98 (0.90–1.06) | 0.27 |
White fish (17.4 g/d) | 1.02 (0.96–1.08) | 1.02 (0.93–1.11) | 1.02 (0.93–1.11) | 0.99 |
Oily fish (21.7 g/d) | 1.01 (0.95–1.07) | 0.94 (0.86–1.03) | 1.06 (0.97–1.15) | 0.08 |
Milk (144 g/d) | 1.03 (0.97–1.10) | 1.06 (0.97–1.16) | 1.00 (0.91–1.10) | 0.37 |
Cheese (17.2 g/d) | 0.96 (0.90–1.03) | 0.96 (0.87–1.05) | 0.96 (0.88–1.06) | 0.93 |
Yogurt (44.5 g/d) | 0.98 (0.93–1.04) | 0.96 (0.87–1.07) | 0.99 (0.92–1.07) | 0.64 |
Fruit and vegetables (172 g/d) | 0.99 (0.92–1.05) | 1.06 (0.97–1.16) | 0.93 (0.85–1.03) | 0.06 |
Energy intake (2.10 MJ/d) | 1.01 (0.95–1.08) | 1.06 (0.96–1.16) | 0.98 (0.89–1.07) | 0.22 |
Protein (2.7% energy) | 1.01 (0.95–1.09) | 1.03 (0.92–1.16) | 1.01 (0.92–1.10) | 0.74 |
Protein from dairy products (1.3% energy) | 1.00 (0.94–1.06) | 1.03 (0.94–1.13) | 0.97 (0.89–1.06) | 0.38 |
Carbohydrate (6.8% energy) | 0.98 (0.92–1.05) | 1.03 (0.93–1.13) | 0.95 (0.87–1.04) | 0.26 |
Total fat (5.4% energy) | 1.01 (0.95–1.07) | 0.99 (0.90–1.09) | 1.02 (0.94–1.11) | 0.61 |
Saturated fat (3.0% energy) | 1.00 (0.94–1.06) | 0.98 (0.89–1.08) | 1.01 (0.92–1.09) | 0.73 |
Monounsaturated fat (2.1% energy) | 1.01 (0.95–1.08) | 1.01 (0.92–1.11) | 1.02 (0.94–1.11) | 0.88 |
Polyunsaturated fat (1.7% energy) | 1.01 (0.95–1.07) | 0.98 (0.90–1.08) | 1.03 (0.95–1.13) | 0.42 |
n-6 fatty acids (1.8% energy)d | 0.97 (0.90–1.05) | 0.98 (0.89–1.08) | 0.95 (0.83–1.10) | 0.77 |
n-3 fatty acids (0.27% energy)d | 1.01 (0.94–1.09) | 1.02 (0.92–1.13) | 1.01 (0.91–1.13) | 0.88 |
Ratio n-6:n-3 (3.7)d | 0.99 (0.92–1.06) | 0.97 (0.89–1.06) | 1.02 (0.90–1.16) | 0.55 |
Alcohol (21.6 g/d) | 1.00 (0.93–1.06) | 0.97 (0.88–1.07) | 1.02 (0.93–1.11) | 0.49 |
Dietary fibre (6.0 g/d) | 0.97 (0.90–1.04) | 1.04 (0.94–1.14) | 0.92 (0.83–1.02) | 0.09 |
Retinol (1055 μg/d) | 1.02 (0.96–1.09) | 1.04 (0.96–1.12) | 1.00 (0.90–1.12) | 0.62 |
Carotene (1568 μg/d)d | 1.01 (0.94–1.08) | 1.05 (0.96–1.15) | 0.94 (0.82–1.07) | 0.17 |
Lycopene (1978 μg/d)d | 0.96 (0.89–1.03) | 0.94 (0.84–1.05) | 0.97 (0.88–1.07) | 0.68 |
Vitamin B6 (0.67 mg/d) | 1.05 (0.98–1.13) | 1.09 (0.98–1.21) | 1.04 (0.94–1.15) | 0.54 |
Folate (90 μg/d) | 1.01 (0.94–1.09) | 1.05 (0.95–1.16) | 1.00 (0.90–1.10) | 0.46 |
Vitamin B12 (3.97 μg/d) | 1.03 (0.96–1.09) | 1.06 (0.98–1.15) | 0.99 (0.89–1.09) | 0.28 |
Vitamin C (52.8 mg/d) | 1.02 (0.95–1.08) | 1.02 (0.92–1.12) | 1.02 (0.94–1.11) | 0.91 |
Vitamin D (2.77 μg/d) | 1.01 (0.95–1.07) | 0.92 (0.83–1.03) | 1.06 (0.98–1.15) | 0.04 |
Vitamin E (4.9 mg/d) | 1.02 (0.95–1.10) | 1.01 (0.91–1.11) | 1.05 (0.94–1.18) | 0.55 |
Calcium (283 mg/d) | 1.03 (0.95–1.11) | 1.05 (0.94–1.18) | 0.99 (0.88–1.11) | 0.46 |
Iron (3.9 mg/d) | 1.00 (0.93–1.08) | 1.00 (0.89–1.12) | 1.02 (0.92–1.15) | 0.75 |
Magnesium (91 mg/d) | 0.98 (0.90–1.06) | 1.02 (0.91–1.14) | 0.96 (0.85–1.08) | 0.48 |
Selenium (34.5 μg/d) | 1.00 (0.94–1.07) | 0.95 (0.85–1.07) | 1.04 (0.96–1.13) | 0.22 |
Zinc (2.53 mg/d) | 0.99 (0.91–1.07) | 1.03 (0.92–1.15) | 0.96 (0.85–1.08) | 0.39 |
Conditional logistic regression adjusted for age, BMI, socioeconomic, smoking and marital status, diabetes and energy intake.
Number of cases and controls.
Test of heterogeneity of trends between cohort studies (mostly clinically-detected disease) and ProtecT (PSA-detected disease).
Unknown for some participants.