Table 1.
Demographic and Clinical Characteristics of Patients With Candida auris Infections in Pakistan, India, Venezuela, and South Africa, 2012–2015
| Patients, No. (%)a | |||||
|---|---|---|---|---|---|
| Characteristic | Total (n = 41) | India (n = 15) | Pakistan (n = 18) | Venezuela (n = 5) | South Africa (n = 3) |
| Age, median (IQR), y | 54(24–69) | 60 (45–79) | 48.5 (40–65) | <1 (<1–11) | 63 (57–73) |
| Age category | |||||
| Neonates (<28 d) | 3 (7) | 0 | 0 | 3 (60) | 0 |
| >28 d to 18 y | 3 (7) | 0 | 2 (11) | 1 (20) | 0 |
| 19–64 y | 21 (51) | 8 (53) | 11 (61) | 0 | 2 (67) |
| ≥65 y | 14 (34) | 7 (47) | 5 (28) | 1 (20) | 1 (33) |
| Male sex | 26 (63) | 10 (71) | 11 (61) | 2 (40) | 3 (100) |
| Underlying conditions | |||||
| Diabetes mellitus | 17 (41) | 9 (60) | 7 (39) | 0 (0) | 1 (33) |
| Solid tumor | 6 (15) | 3 (20) | 3 (17) | 0 (0) | 0 |
| Hematological malignancy | 0 (0) | 0 | 0 | 0 | 0 |
| Liver disease | 4 (10) | 2 (13) | 2 (11) | 0 | 0 |
| Corticosteroid therapy during hospitalization | 10 (24) | Unknown | 10 (56) | 0 | 0 |
| Other exposures | |||||
| Surgery in 90 d before diagnosis of C. auris infection | 21 (51) | 10 (67) | 5 (28) | 4 (80) | 2 (67) |
| Central venous catheter | 30 (73) | 7 (54) | 16 (89) | 5 (100) | 2 (67) |
| Urinary catheter | 25 (61) | 8 (62) | 16 (89) | Unknown | 1 (33) |
| Antifungal treatment in 90 d before diagnosis of C. auris infection | 17 (41) | 4 (11) | 9 (50) | 4 (80) | 0 |
| Time from admission to culture, median, (IQR), d | 19 (9–36) | 19 (9–25) | 27 (8–43) | 18 (17–24) | 19 (13–24) |
| Site of C. auris infection | |||||
| Blood | 25 (61) | 8 (53) | 11 (61) | 5 (100) | 1 (33) |
| Urine | 7 (17) | 0 (0) | 6 (33) | 0 | 1 (33) |
| Respiratory tract | 2 (5) | 2 (13) | 0 (0) | 0 | |
| Other | 7 (17) | 5 (33) | 1 (6) | 0 | 1 (33) |
| Antifungal treatment after C. auris diagnosis | |||||
| None | 15 (37) | 5 (33) | 7 (39) | 1 (20) | 2 (67) |
| Amphotericin B | 15 (37) | 2 (13) | 10 (56) | 2 (40) | 1 (33) |
| Fluconazole | 9 (22) | 5 (33) | 2 (11) | 2 (40) | 0 |
| Voriconazole | 2 (5) | 1 (7) | 0 | 1 (20) | 0 |
| Caspofungin | 8 (20) | 6 (43) | 0 | 2 (40) | 0 |
| In-hospital deaths | 24 (59) | 7 (47) | 13 (72) | 3 (60) | 1 (33) |
Abbreviation: IQR, interquartile range.
aData represent No. ( %) of patients unless otherwise specified.