Table 2.

Association of CUBN positivity with clinicopathological parameters in ccRCC

Variable	Cohort 2				Cohort 3
	N	CUBN negative N (%)	CUBN positive N (%)	P-value	N	CUBN negative N (%)	CUBN positive N (%)	P-value
Spread at diagnosis	131				114
Local		50 (96)	72 (91)			15 (33)	39 (57)
Metastatic		2 (4)	7 (9)	0.317b		31 (67)	29 (43)	0.009a
T-Stage	123
T1-T2		5 (10)	14 (19)		n.a.
T3-T4		45 (90)	59 (81)	0.167a
Fuhrman Grade	95
1–2		8 (23)	31 (52)		n.a.
3–4		27 (77)	29 (48)	0.006a
Nodal Status	131
Negative		39 (75)	73 (92)		n.a.
Positive		13 (25)	6 (8)	0.006a

N number of patients

^aχ² test

^bFisher’s exact test; n.a., not available