Table 1.
Overview of significant decreases in functional connectivity after citalopram as estimated with threshold‐free cluster enhancement (P < 0.05, corrected)
| Network | NPC/T | Region (Harvard–Oxford) | z* | x | y | z | # voxels | |
|---|---|---|---|---|---|---|---|---|
| Sensorimotor network | NPC | L/R/M | ACC, PCC, precuneus, SMA, post‐ and precentral gyrus, medial, and orbital frontal cortex | 5.23 | −22 | 50 | −16 | 27,308 |
| L/R/M | Cerebellum | 4.28 | 0 | −72 | −30 | 1,696 | ||
| L/M | Lateral occipital cortex, inferior, and superior division | 4.20 | −14 | −92 | 20 | 585 | ||
| R | Cerebellum and temporal occipital fusiform cortex | 3.92 | 36 | −78 | −22 | 530 | ||
| R/M | Occipital pole and lingual gyrus | 3.28 | 8 | −96 | −6 | 92 | ||
| L | Superior frontal gyrus | 3.25 | −18 | 32 | 28 | 91 | ||
| Sensorimotor network | T = 4.5 | L/R/M | ACC, PCC, precuneus, SMA, brain stem, post‐ and precentral gyrus, orbital frontal cortex and cerebellum, lateral occipital cortex, inferior, and superior division | 5.03 | −14 | −92 | 20 | 46,242 |
| L | Insular cortex, temporal, and frontal opercular cortex | 4.91 | −38 | 16 | −4 | 498 | ||
| M | Thalamus | 4.72 | 2 | −12 | 18 | 212 | ||
| Frontoparietal network right | NPC | M | Brain stem | 4.42 | 2 | −26 | −16 | 55 |
| Frontoparietal network right | T = 3.5 | R | Insular and central opercular cortex | 5.22 | 40 | 4 | 4 | 41 |
| R | Insular cortex and Heschl's gyrus | 4.53 | 40 | −16 | 4 | 11 | ||
| Frontoparietal network right | T = 4.5 | L/R/M | Brain stem and cerebellum | 4.43 | 8 | −44 | −18 | 1,655 |
| L | Frontal orbital cortex | 3.72 | −26 | 8 | −14 | 45 | ||
| L | Parietal opercular cortex | 3.78 | −32 | −44 | 28 | 34 | ||
| Default mode network | T = 4.5 | L/R | Cerebellum | 5.14 | −22 | −78 | −24 | 5,374 |
| L/M | Precuneus, PCC, hippocampus, temporal, and supramarginal gyrus | 4.56 | −36 | −58 | 28 | 2,407 | ||
| L | Lateral occipital cortex, inferior, and superior division | 4.40 | −28 | −82 | 8 | 134 | ||
| Executive control network | T = 6 | R | Precentral gyrus, inferior, and middle frontal gyrus | 4.63 | 42 | 16 | 20 | 302 |
| R | Superior and middle frontal gyrus | 4.48 | 28 | 2 | 58 | 213 | ||
| R | Lateral occipital cortex, inferior, and superior division | 3.91 | 56 | −70 | −4 | 187 | ||
| R | Inferior temporal gyrus | 4.07 | 54 | −44 | −24 | 37 | ||
| R | Parietal operculum cortex | 5.21 | 36 | −36 | 20 | 19 | ||
| R | Precentral gyrus | 4.18 | 42 | 0 | 32 | 15 |
Abbreviations: L, left; R, right; M, midline; ACC, anterior cingulate cortex; PCC, posterior cingulate cortex; SMA, supplementary motor area. Voxel dimension = 2 mm × 2 mm × 2 mm (voxel volume 0.008 mL). * = standardized z‐value of the uncorrected peak Fisher‐ (NPC) or t‐statistic (partial tests) within regions.