Table 2.

Overview of significant decreases (↓) and increases (↑) in functional connectivity after galantamine as estimated with threshold‐free cluster enhancement (P < 0.05, corrected)

Network	NPC/T	Region (Harvard–Oxford)		z*	x	y	z	# voxels
Visual network 2 (↑)	NPC	L/R/M	Hippocampus, thalamus, precuneus, PCC, lateral occipital cortex, brain stem, fusiform gyrus, superior frontal gyrus, precentral gyrus, and cerebellum	4.84	2	−62	−26	10,765
		L/M	Cerebellum and brain stem	4.21	8	−48	−44	1,249
		M	Precuneus and PCC	3.10	−8	−40	54	147
		R	Frontal orbital cortex	4.09	34	32	0	31
		R	Inferior frontal gyrus	3.56	48	14	14	25
		R	Frontal operculum cortex	3.40	50	10	−2	16
Default mode network (↓)	T = 2.5	R/M	Precuneus, PCC, and calcarine cortex	4.36	10	−58	26	210
		R	Lateral occipital cortex, superior division	4.34	40	−72	28	74
		M	Lingual gyrus	3.70	4	−54	2	15
Visual network 1 (↓)	T = 3.5	M	ACC and paracingulate gyrus	4.41	8	22	18	246
		R	Precuneus and PCC	3.64	14	−56	16	210
		R	Superior temporal gyrus, Heschl's gyrus, and planum polare	4.06	48	−26	0	105
		R/M	ACC, paracingulate gyrus, superior, and inferior frontal gyrus	3.65	14	8	38	93
		L	Lingual gyrus, parahippocampal gyrus	3.46	−18	−46	−12	91
		R	Pallidum, amygala, and putamen	4.54	18	2	−8	76
Visual network 2 (↑)	T = 3.5	R	Cerebellum	4.79	24	−66	−36	14
Visual network 2 (↑)	T = 6	L/R/M	Hippocampus, parahippocampal gyrus, cerebellum, brain stem, temporal occipitalfusiform cortex and inferior temporal gyrus	5.01	8	−48	−44	4,876
		R	Lateral occipital cortex, superior division	4.24	28	−62	52	677
		R	Precentral gyrus, superior, and middle frontal gyrus	3.85	32	−8	38	470
		R	PCC, precuneus, and precentral gyrus	4.32	14	−24	44	372
		L	Precuneus and lateral occipital cortex, superior division	3.66	−18	−68	52	152
		R	Lateral occipital cortex, superior division	3.62	42	−76	30	146
Frontoparietal network left (↓)	T = 4.5	L/R/M	Frontal medial cortex and ACC	5.25	−2	52	−2	630
		R	Precuneus and PCC	4.12	16	−50	12	110
		R	Parahippocampal gyrus, posterior division	4.53	12	−30	−16	44
		R	Temporal occipital fusiform cortex and lingual gyrus	3.44	36	−42	−10	14
Auditory network (↑)	T = 6	L/M	PCC, precuneus, and precentral gyrus	4.83	−4	−32	48	188
		L	Postcentral gyrus	4.65	−46	−28	50	23

Abbreviations: L, left; R, right; M, midline; ACC, anterior cingulate cortex; PCC, posterior cingulate cortex. Voxel dimension = 2 mm × 2 mm × 2 mm (voxel volume 0.008 mL). * = standardized z‐value of the uncorrected peak Fisher‐ (NPC) or t‐statistic (partial tests) within regions.