Figure 2.

Effect of MMEJ components knock‐down on plasmid genomic integration and expression. CHO cells were treated with siRNAs against the indicated MMEJ genes and processed as described in the legend to Figure 1. The average GFP fluorescence (A), GFP copy number (B), GFP expression per transgene copy (C), and frequency of genomic integration events (D) were assessed and represented as in Figure 1 (n ≥ 3).