Table 4.

Metabolite COVs for Voxels Containing Spectra That Meet “Acceptable” Water Line Width Criteria

	0.06‐0.1ppm
	TE = 35 ms		TE = 80 ms		TE = 144 ms		Echo time comparison
Line width	COV %		COV %		COV %		ANOVA
Metabolite	Si.BL	Ex.BL	Si.BL	Ex.BL	Si.BL	Ex.BL	Si.BL	Ex.BL
tNAA††¥¥	11.94	8.41	6.77	5.92	14.73	8.27	<0.00001	<0.0001
tCr	9.78	9.74	8.12	8.33	14.02	12.73	<0.00001	<0.001
tCho	9.75	10.47	9.00	8.98	10.89	11.03	0.2815	0.1056
Glu†	23.06	18.63	24.45	24.68	62.45	59.21	<0.00001	<0.00001
Gln	83.65	85.64	61.78	65.36	48.18	54.81	<0.00001	<0.00001
Glx†	29.56	23.99	24.41	24.54	23.34	26.99	0.01	0.3328
Ins	14.85	15.06	19.49	20.47	47.85	45.72	<0.00001	<0.00001
Glth†	63.00	102.50	28.71	28.53	92.26	88.03	<0.00001	<0.00001
Tau††	128.16	96.08	73.74	74.43	91.93	86.37	<0.00001	<0.01

Metabolite COVs for TE = 35, 80, and 144 ms for voxels containing spectra that meet the “acceptable” water line width criteria of between 0.06 and 0.1ppm showing significant (P < 0.05) differences from an unpaired t‐test between Si.BL and Ex.BL for TE = 35 ms (†), TE = 80 ms (‡), and TE = 144 ms (¥). Significances of P < 0.01 are denoted as: TE = 35 ms (††), TE = 80 ms (‡‡), and TE = 144 ms (¥¥).