Table 1. Diseases and Functions Predicted to be Inhibited by TGF-β3.

Diseases or Functions Annotation	p-Value	Activation z-score
cell proliferation of tumor cell lines	1.12x10-21	-4.04
proliferation of cells	8.90x10-43	-3.66
cell proliferation of breast cancer cell lines	5.79x10-11	-3.29
metabolism of DNA	1.35x10-9	-3.07
M phase of tumor cell lines	1.46x10-10	-2.92

IPA was used to predict diseases or functions inhibited by TGF-β3. p-Values indicated the degree of overlap between differentially expressed genes between TGF-β untreated and TGF-β3 treated samples and genes in the gene set by Fisher’s exact test, and z-scores are indicators of the activation or inhibition based on the Downstream Effects Analysis algorithm[31]. Five functions with the lowest activation z-scores are shown.