Table 1. Diseases and Functions Predicted to be Inhibited by TGF-β3.
Diseases or Functions Annotation | p-Value | Activation z-score |
---|---|---|
cell proliferation of tumor cell lines | 1.12x10-21 | -4.04 |
proliferation of cells | 8.90x10-43 | -3.66 |
cell proliferation of breast cancer cell lines | 5.79x10-11 | -3.29 |
metabolism of DNA | 1.35x10-9 | -3.07 |
M phase of tumor cell lines | 1.46x10-10 | -2.92 |
IPA was used to predict diseases or functions inhibited by TGF-β3. p-Values indicated the degree of overlap between differentially expressed genes between TGF-β untreated and TGF-β3 treated samples and genes in the gene set by Fisher’s exact test, and z-scores are indicators of the activation or inhibition based on the Downstream Effects Analysis algorithm[31]. Five functions with the lowest activation z-scores are shown.