Table 2.

Clinical Characteristics of Irish R304^*–Positive Somatotrophinoma Patients (NI Acromegaly Registry, Dublin patients and FIPA Consortium database) Compared to AIPmut–Negative Irish Patients with Somatotrophinomas (NI and Dublin Patients)

AIP genotype	Heterozygous NM_003977.3:c.910C>T n = 31	Homozygous wild‐type n = 96	P value
Median age (range) at onset (years)	17 (6–68) (n = 29)	38.5 (14–85) (n = 64)	<0.0001
Median age (range) at diagnosis (years)	19.5 (7–68) (n = 30)	46 (19–85) (n = 95)	<0.0001
Age <30 years at disease onset	27/31 (87.1%)	21/96 (21.9 %)	<0.0001
Mean tumor size (mm)	23.8 ± 10.6 (n = 11)	17.2 ± 8.4 (n = 43)	<0.05
Pituitary macroadenoma	22/24 (91.7%)	58/70 (82.9%)	ns
Gigantism	18/31 (58.1%)	7/96 (7.3%)	<0.0001
Family history of PA	24/31 (77.4%)	3/94 (3.2%)	<0.0001

ns = not significant