Table 1.
Baseline characteristics of the male and female samples by incident aMCI status. Values are mean (SD) unless otherwise noted.
| Women | Men | |||||
|---|---|---|---|---|---|---|
| Background Characteristics |
All N=572 |
No Incident aMCI N=482 |
Incident aMCI N=90 |
All N=345 |
No Incident aMCI N=281 |
Incident aMCI N=64 |
| Age at baselineW, M | 77.98 (6.0) | 77.69 (5.2) | 79.52 (6.0) | 77.28 (5.1) | 76.86 (5.0) | 79.12 (5.1) |
| Education (years)W | 13.82 (3.3) | 14.00 (3.4) | 12.86 (2.9) | 14.17 (3.6) | 14.11 (3.5) | 14.41 (3.6) |
| Caucasian, N (%)S | 365 (64) | 304 (63) | 61 (68) | 268 (78) | 219 (76) | 49 (77) |
| Follow-up time, yrsM | 4.19 (3.2) | 4.27 (3.3) | 3.73 (2.9) | 4.24 (3.2) | 4.48 (3.3) | 3.21 (2.8) |
| Time to aMCI onset, yrs (aMCI-positive participants only) | – | – | 3.7 | – | – | 3.2 |
| APOE4 carriera, N (%) | 81 (23) | 61 (22) | 20 (29) | 45 (21) | 35 (20) | 10 (24) |
| Cardiovascular comorbidity indexS | 1.00 (0.9) | 0.99 (0.9) | 1.05 (0.9) | 1.13 (1.0) | 1.15 (1.1) | 1.03 (0.99) |
| Antidepressant medication, N (%)M | 21 (4) | 18 (4) | 3 (3) | 11 (3) | 6 (2) | 6 (9) |
| History of clinical depression, N (%) | 56 (10) | 47 (10) | 9 (10) | 29 (8) | 22 (8) | 7 (11) |
Notes. The F-test in univariate analyses of variance was used to test mean differences in continuous variables between incident aMCI groups in women, F(1,570) and men, F(1,343) separately. Chi-square tests were used to test differences in frequencies between incident aMCI groups in women, X2 (df=1,N=572) and men X2, (df=1, N=345) separately. Abbreviations: aMCI = amnestic mild cognitive impairment. APOE4 = apolipoprotein ε4 allele.
APOE genotype was available for only 347 women and 217 men.
There is a significant difference between sexes at p<0.05.
Main effect of incident aMCI status is significant in men at p<0.05.
Main effect of incident aMCI status is significant in women at p<0.05.