Table 2.
Baseline characteristics of the male and female samples by depressive symptom group. Values are means (SD) unless otherwise noted.
| Women (N=572) | Men (N=345) | |||||
|---|---|---|---|---|---|---|
| Background Characteristics |
No/Low Depressive Symptoms N=384 |
Mild Depressive Symptoms N=135 |
Moderate/Severe Depressive Symptoms N=53 |
No/Low Depressive Symptoms N=254 |
Mild Depressive Symptoms N=64 |
Moderate/Severe Depressive Symptoms N=27 |
| Age at baseline | 77.86 (5.4) | 78.36 (5.5) | 77.89 (5.1) | 77.07 (5.1) | 77.61 (5.2) | 78.5 (5.4) |
| Education (years)W | 14.14 (3.4) | 13.10 (3.0) | 13.34 (3.6) | 14.21 (3.6) | 13.86 (3.6) | 14.48 (3.5) |
| Caucasian, N (%) | 242 (63) | 90 (67) | 33 (62) | 195 (77) | 50 (78) | 23 (85) |
| APOE4 carriera, N (%) | 60 (26) | 15 (17) | 6 (21) | 38 (24) | 5 (12) | 2 (12) |
| Follow-up time, yrsM | 4.38 (3.3) | 3.90 (3.1) | 3.47 (2.7) | 4.57 (3.4) | 3.16 (2.3) | 3.68 (2.8) |
| Incident aMCI cases, N (%)M | 54 (14) | 24 (18) | 12 (23) | 44 (17) | 19 (30) | 1 (4) |
| Incident naMCI cases, N (%)M | 58 (15) | 28 (21) | 13 (25) | 39 (15) | 17 (26) | 1 (4) |
| Time to aMCI onset, yrs (aMCI-positive participants only) | 4.0 (3.1) | 3.5 (2.8) | 3.0 (2.3) | 3.6 (3.0) | 2.3 (2.0) | 1.3 (na)b |
| Cardiovascular comorbidity indexW, M | 0.88 (0.8) | 1.18 (0.9) | 1.38 (1.1) | 1.06 (1.0) | 1.17 (1.0) | 1.70 (1.3) |
| Antidepressant medication, N (%)W | 9 (2) | 8 (6) | 4 (8) | 6 (2) | 4 (6) | 2 (7) |
| History of clinical depression, N (%)W, M | 28 (7) | 17 (13) | 11 (21) | 17 (7) | 6 (9) | 6 (22) |
Notes. The F-test in univariate analyses of variance was used to test mean differences in continuous variables between depressive symptom groups in women, F(1,570) and men, F(1,343) separately. Chi-square tests were used to test differences in frequencies between depressive symptom groups in women, X2 (df=2, N=572) and men, X2 (df=2, N=345) separately. Abbreviations: aMCI = amnestic mild cognitive impairment. naMCI = non-amnestic mild cognitive impairment. GDS = Geriatric Depression Scale. APOE4 = apolipoprotein ε4 allele.
APOE genotype was available for only 347 women and 217 men.
No standard deviation is available for mean time to aMCI onset in men reporting moderate/severe depressive symptoms because only one incident aMCI case in this group.
Main effect of depressive symptom group is significant in men at p<0.05.
Main effect of depressive symptom group is significant in women at p<0.05.