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. 2016 May 24;17(1):19–34. doi: 10.3727/105221616X691631

Figure 5.

Figure 5

T3- and GC-1-induced proliferation is blunted in the absence of redundant Wnt coreceptors LRP5-6 in hepatocytes. (A) BrdU and cyclin D1 immunohistochemistry shows decreased staining of hepatocytes in LRP5-6-LKO as compared to littermate controls in response to T3 and GC-1 administration. Continued staining of smaller nonparenchymal cells is observed in controls and LRP5-6-LKO in response to T3 and GC-1 (100×). (B) Bar graph shows a significant decrease in the number of hepatocytes displaying BrdU-positive nuclei per HPF (400×) in the liver sections of LRP5-6 versus controls in response to T3 and GC-1 (***p < 0.001). (C) Normalizing BrdU counts to their respective controls show that LRP5-6-LKO shows comparably reduced percentage of hepatocyte labeling in response to T3 and GC-1.