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Mechanism of T3/GC-1-induced β-catenin activation leading to cyclin D1 expression and cell proliferation. In hepatocytes, T3/GC-1 appears to activate β-catenin via PKA-dependent mechanism as well as through canonical Wnt signaling. It is likely that T3/GC-1 may induce β-catenin activation in endothelial cells to induce cell proliferation and also may stimulate Wnt release to activate β-catenin in hepatocytes in a paracrine fashion.
