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. 2016 Nov 12;44(12):3056–3066. doi: 10.1111/ejn.13442

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© 2016 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Overexpression of human tau does not cause tangle formation or increase tau hyperphosphorylation. PHF1 positive tau accumulates in neuropil threads in APP/PS1/rTg21221 mice (A) and in dystrophic neurites in both APP/PS1/rTg21221 (B) and APP/PS1 mice (C). A western blot of crude homogenate from the cortex of a mouse (5 μg protein) was probed for PHF1 (D) and GAPDH (E) as a loading control. The PHF1 bands between 55–65 kDa were quantified and the overexpression of human tau did not change the overall levels of PHF1 (F). APP/PS1/rTg21221 n = 6, APP/PS1n = 3, rTg21221 n = 4 Scale bar 5 μm. [Colour figure can be viewed at wileyonlinelibrary.com].